Malaria-Proof Mosquito?

Aug 12, 2010

annadrexlersmall
annadrexlersmall
A malaria-proof mosquito?

Research news coming out of the University of California, Davis and the University of Arizona labs recently drew international attention; the scientists have genetically engineered mosquitoes that are resistant to malaria parasites.

Now one of the co-authors has received a coveted research fellowship from the National Institutes of Health (NIH).

luckhart
luckhart
Entomology doctoral student Anna Drexler (top photo)
who studies with noted malaria researcher and major professor Shirley Luckhart (left), has received a NIH research fellowship aimed to promote diversity in health-related research.

Luckhart is an associate professor in the Department of Medical Microbiology and Immunology, UC Davis School of Medicine, and a graduate student advisor in the UC Davis Department of Entomology.

Drexler, who joined the Luckhart lab in January 2008, focuses her research on the roles of the human blood-derived insulin-like growth factor-1 and the role of insulin signaling in the regulation of malaria parasite transmission by Anopheles mosquitoes.

The UC Davis student is a co-first author of a paper on malaria parasites published July 15, 2010 in the journal Public Library of Science Pathogens (PLOS). Titled “Activation of Akt Signaling Reduces the Prevalence and Intensity of Malaria Parasite Infection and Lifespan in Anopheles stephensi Mosquitoes,” the work is a collaborative effort between UC Davis and the University of Arizona.

Co-authors include Luckhart and UC Davis researcher Ed Lewis, who has a joint appointment with the Department of Nematology and the Department of Entomology.

The paper, with more than 4200 article views in July alone, has drawn extensive news coverage. BBC science reporter Victoria Gill, in a July 16th article headlined “Malaria-Proof Mosquito Engineered,” wrote that the scientists “have succeeded in genetically engineering a malaria-resistant mosquito.”

In a July 17th piece, “Malaria-Proof Mosquito Created,” ABC News science writer Eric Bland wrote that scientists have created a malaria-proof mosquito by engineering "a genetic ‘on switch' that permanently activates a malaria-destroying response.”

“If these mosquitoes,” Bland wrote, “are successfully introduced into the wild, they could prevent millions of people from becoming infected with life-threatening Plasmodium--the parasite that causes malaria.”

Drexler, who grew up in Washington, D.C., received her bachelor’s degree in integrative biology, with an emphasis on animal biology, from UC Berkeley in 1999. She earned  her master’s degree in physiology and behavior from San Francisco State University in 2006.

The competitive NIH fellowships are available to provide funds to qualified students for stipends, research supplies, and research-related travel under an existing parent research grant.

The applications are evaluated on multiple criteria, including career goals, prior research training, research potential and relevant experience, and evidence of educational achievement.

This research is so important: targeting a killer that causes more than a million human deaths a year worldwide.


By Kathy Keatley Garvey
Author - Communications specialist

Attached Images:

MALARIA MOSQUITO--Through blood-feeding, an infected malaria mosquito transmits the parasites causing the killer disease, malaria. (Photo of Anopheles gambiae by Anton Cornel, UC Kearney Agricultural Center/UC Davis.)

Malaria Mosquito